An Indian Scenario for Polymorphous Light Eruption

Abstract

A common photodermatosis known as polymorphous light eruption (PLE) is characterized by a delayed hypersensitivity reaction to sunlight. This study focuses on the epidemiology, clinical characteristics, pathophysiology, diagnosis, and therapy of PLE in the Indian population. India has a higher prevalence of PLE than other regions due to its geographic position and high levels of ambient ultraviolet (UV) light. Papular and erythematous lesions, face involvement, and persistent/recurrent nature are prevalent characteristics of the clinical presentation of PLE in Indians, which frequently varies from other populations. Genetic susceptibility, ultraviolet exposure, and immunological dysregulation are all factors in the pathophysiology of PLE, with particular implications for the Indian population. The mainstay of diagnosis is clinical evaluation, which is backed up by phototesting and histological analysis. The use of topical and systemic medicines, phototherapy, and sun protection measures are all examples of management techniques. Complementary therapies are also promising in the therapy of PLE. In order to improve patient care and quality of life, this review aims to increase understanding and promote customized approaches to PLE in the Indian setting. To further understand the precise genetic and environmental factors that affect PLE in Indians and to create focused treatments, more investigation is required.