Influence of Haemoglobin Variants in Sickle Cell Anaemic Children Between 1 to 12 Year Ages from Western Maharashtra
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Abstract
Introduction: Sickle cell anaemia is a molecular disease. WHO recognise it as a global public health problem. In India it is common among tribal community. HbA0, HbS, HbF and HbA2 are common Hb variant found in blood. Therapeutic research is focused on maintaining high level of HbF. Naturally compensated Hb variants may have influence in SCA. Aim: To assess the role of naturally available variants in blood of SCA patients. Result: We observed low level of Total Hb, and elevated levels of HbF, HbA2 along with decrease level of HbA0. Higher than normal level of HbF in SCA patient have lowered osmotic fragility and less frequency of clinical crises. Conclusion: Low HbA0 is compensated by other haemoglobin variants and particularly high level of naturally compensated HbF and HbA2 in sickle cell anaemic patients have beneficial influence.
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