Formulation and Evaluation of Hydroxychloroquine Sulfate Nasal Spray for SARS Covid 19 Virus
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Abstract
Rapid spread of SARS Covid 19 turned out to be a global emergency. Covid 19 RNA virus strain is from family Coronaviridae. Phylogenetic analysis of complete viral genome revealed that virus was most closely related to SARS like coronaviruses.Symptoms of viral infection include mild infection of upper repiratory tract, viral pneumonia, respiratory failure and death. Hydroxychloroquine (HCQ) has demonstrated positive results indicating a potential role against SARS Covid 19 virus. Mechanism of action includes ;interference in endocytic pathway, blockade of sialic acid receptors, restriction of pH mediated spike (S) protein cleavage at the Angiotensin converting enzyme (ACE 2) binding site and prevention of cytokine storm.Yet clinical trials have been carried out to evaluate its abilityand turning it into a needed drug. Existing literature hints the role of Hydroxychloroquine (HCQ) sulfate in Covid 19 for obtaining a therapeutic option for the pandemic.
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References
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