Formulation, Optimization and Evaluation of Ocular Inserts Containing Anti-Fungal Drug.

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Rohit Jadhav
Vaibhav Vaidya
Mohit Mahajan
Prachi Farande
Shrutika Bhagde
Abhishek Galgate


The goal of the current study was to create Clotrimazole betacyclodextrin  ocuserts and assess the physicochemical aspects of in vitro release and . For improved ocular bioavailability and retention of the drug, several polymeric methods are employed to create ocular inserts. Gelling systems have shown benefits of simple administration and prolonged contact time. Utilizing gelatin as film-forming polymers and glycerin as a plasticizer, Clotrimazole beta-cyclodextrin ocular inserts were prepared. Beta-Cyclodextrin was complexes with Clotrimazole so that the solubility of the Clotrimazole can be increased. Solid dispersion of Clotrimazole was done to increase its solubility. Thirteen formulations in all were made using the solvent casting technique and evaluated for their surface pH, thickness, weight fluctuation, drug content, moisture loss, and in vitro and in vivo release tests. Excised goat cornea was placed between the donor and receptor compartments of Franz diffusion cells for the in vitro release tests. At the conclusion of two hours, Formulation F9 exhibits a maximum cumulative percentage drug release via excised goat cornea of 72.62%.

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Rohit Jadhav, Vaibhav Vaidya, Mohit Mahajan, Prachi Farande, Shrutika Bhagde, & Abhishek Galgate. (2023). Formulation, Optimization and Evaluation of Ocular Inserts Containing Anti-Fungal Drug. Journal of Coastal Life Medicine, 11(2), 252–259. Retrieved from


Dhanapal R,Ratna JV. Ocular drug delivery system–a review International journal of innovative drug discovery. 2012;2(1):4-15.

Tangri P, Khurana S. Basics of Ocular Drug Delivery Systems. Int. J. Res. Pharm. Biomed. Sci, 2011; 2(4):1541-1552.

Shivhare UD, Bobade RS. Formulation and evaluation of ocular in. 2013;2:4:1846–51

Bharath S. Sustained ophthalmic delivery of ofloxacin from an ionactivated in situ gelling system. Pak J Pharm.2009; 22(2):175-9.

Gevariya Hitesh B. “Formulation and evaluation of sustainedrelease ocular drug delivery system for an anti-glaucomadrug”. Saurashtra University (2013): 1-21.

M. M. A. Abdel-Mottaleb, N. D. Mortada, A. A. Elshamy, and G. A. S. Awad, “Preparation and evaluation of fluconazolegels,” Egyptian Journal of Biomedical Science, vol. 23, pp. 266–286, 2007.

G. L. Amidon, H. Lennernas, V. P. Shah, and J. R. Crison, “Atheoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivobioavailability,” Pharmaceutical Research, vol. 12, no. 3, pp.413–420, 1995

Abdul Ahad H, Sreeramulu J, Padmaja BS, Reddy MN, Prakash PG. Preparation of Fluconazole