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The goal of the current study was to create Clotrimazole betacyclodextrin ocuserts and assess the physicochemical aspects of in vitro release and . For improved ocular bioavailability and retention of the drug, several polymeric methods are employed to create ocular inserts. Gelling systems have shown benefits of simple administration and prolonged contact time. Utilizing gelatin as film-forming polymers and glycerin as a plasticizer, Clotrimazole beta-cyclodextrin ocular inserts were prepared. Beta-Cyclodextrin was complexes with Clotrimazole so that the solubility of the Clotrimazole can be increased. Solid dispersion of Clotrimazole was done to increase its solubility. Thirteen formulations in all were made using the solvent casting technique and evaluated for their surface pH, thickness, weight fluctuation, drug content, moisture loss, and in vitro and in vivo release tests. Excised goat cornea was placed between the donor and receptor compartments of Franz diffusion cells for the in vitro release tests. At the conclusion of two hours, Formulation F9 exhibits a maximum cumulative percentage drug release via excised goat cornea of 72.62%.
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