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The objective of this study was to optimize, design and evaluate the in situ nasal gel of Memantine Hydrochloride in Alzheimer’s disease. In situ nasal gel was prepared by cold method and was optimized by the Box-Behnken design using Design- Expert Software (version 13). Concentration of polymer (%) (Poloxamer 407), concentration of gelling agent (%) HPMC and stirring speed (rpm) were selected as a independent variables, whereas viscosity(mpa), drug release (%) and gelation time (sec) were selected as a dependent variables. All the batches were assessed for various parameters such as viscosity (mpa), drug release (%), gelation time (sec), pH, drug content and gel strength. The F1 was found as an optimized formulation of nasal insitu gel. The optimized formulation of the insitu nasal gel for Alzheimer's disease was found to have a viscosity of 3867 ± 5.5 mpa, drug release of 77.02 %, and a gelation time of 48 sec respectively. These results indicate that the nasal insitu gel was able to maintain its viscosity over time and was able to release the drug at a sustained rate over the course of the study. The gelation time was also found to be within an acceptable range, indicating that the gel was able to form in the nasal cavity. These results suggest that the developed Memantine Hydrochloride insitu nasal gel may be the promising drug delivery for Alzheimer’s disease.
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