Risk Assessment and Development of Collagen/PVA Nano-Fibrous E Spun Scaffolds for Improving Wound Healing Rate
Main Article Content
Abstract
Chronic wound is a major challenge worldwide. It imparts burden over Health-Related Quality of Life. Use of Natural Polymers has imparted to body’s native Extracellular Matrix rejuvenating structure and elasto-mechanical characteristics in tissue regeneration and these novel nanofibric composites act far better compared to conventional formulation over loss of medicament (gel, ointment, cream) , adherence to the skin, ease of application and removal if any complications. Recent trends over the use of Electrospinning for the fabrication of fibrous composites ease the preparation with the economic benefits. Comparative market search states the leading gap over the Indian products for wound healing composites and need to be concerned to prioritize research in regenerative tissue scaffolds and its manufacturing techniques. Risk Assessment tool comprehends predictive variability and its impact towards the quality of product. Planning a control strategy for the process with the OFAT approach for the optimization of the process can give a higher quality product. The optimized batch was blended with the Poly (vinyl alcohol) and Collagen for the fabrication of nanofibers. Characterization states the high porous network was formed. This nano fibrous scaffolds were subjected to in-vivo animal model for wound healing. Based on results of requisite findings, it can be concluded that novel composites serves a promising approach over the compromised wound healing.
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References
Izadi K, Ganchi P. Chronic wounds. Clin Plast Surg. 2005;32(2):209–22.
Marazzi P. Chronic wounds. Pract Nurse. 2019;49(3):689–700.
Järbrink K, Ni G, Sönnergren H, Schmidtchen A, Pang C, Bajpai R, et al. Prevalence and incidence of chronic wounds and related complications: A protocol for a systematic review. Syst Rev [Internet]. 2016;5(1):1–6. Available from: http://dx.doi.org/10.1186/s13643-016-0329-y
Järbrink K, Ni G, Sönnergren H, Schmidtchen A, Pang C, Bajpai R, et al. The humanistic and economic burden of chronic wounds: A protocol for a systematic review. Syst Rev [Internet]. 2017;6(1):1–7. Available from: http://dx.doi.org/10.1186/s13643-016-0400-8
Darwin E, Tomic-Canic M. Healing Chronic Wounds: Current Challenges and Potential Solutions. Curr Dermatol Rep. 2018;7(4):296–302.
Olsson M, Järbrink K, Divakar U, Bajpai R, Upton Z, Schmidtchen A, et al. The humanistic and economic burden of chronic wounds: A systematic review. Wound Repair Regen. 2019;27(1):114–25.
Zhao R, Liang H, Clarke E, Jackson C, Xue M. Inflammation in chronic wounds. Int J Mol Sci. 2016;17(12):1–14.
Nikolova MP, Chavali MS. Recent advances in biomaterials for 3D scaffolds: A review. Bioact Mater. 2019;4(October):271–92.
Karl T. Chronic wounds. Gefasschirurgie. 2023;28(1):5–6.
Singh S, Young A, McNaught CE. The physiology of wound healing. Surg (United Kingdom) [Internet]. 2017;35(9):473–7. Available from: http://dx.doi.org/10.1016/j.mpsur.2017.06.004
Application F, Data P, Group PE. United States Patent [ 19 ] [ 11 ] Patent Number : [ 45 ] Date of Patent : 1995;(19):3–6.
Hong WS, Oh CM. Thermal shock reliability of low Ag composition Sn-0.3Ag-0.7Cu and near eutectic Sn-3.0Ag-0.5Cu Pb-free solder joints. J Korean Inst Met Mater. 2009;47(12):842–51.
Zhang P, Lu J, Jing Y, Tang S, Zhu D, Bi Y. Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis†. Ann Med. 2017;49(2):106–16.
Das S, Baker AB. Biomaterials and nanotherapeutics for enhancing skin wound healing. Front Bioeng Biotechnol. 2016;4(OCT):1–20.
Wang PH, Huang BS, Horng HC, Yeh CC, Chen YJ. Wound healing. J Chinese Med Assoc [Internet]. 2018;81(2):94–101. Available from: https://doi.org/10.1016/j.jcma.2017.11.002
Tabata Y. Tissue Regeneration Based on Drug Delivery Technology. Top Tissue Eng. 2003;1–32.
Harding KG, Morris HL, Patel GK. Healing chronic wounds The clinical burden of wounds. Br Med J [Internet]. 2002;324(January):160–3. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1122073/pdf/160.pdf
Janik H, Marzec M. A review: Fabrication of porous polyurethane scaffolds. Mater Sci Eng C [Internet]. 2015;48:586–91. Available from: http://dx.doi.org/10.1016/j.msec.2014.12.037
Pany S, Sen SK, Prasanna G, Pati S, Pal BB. Spectrum of Bacterial Infections Associated with Diabetic Ulcer Patients. J Pure Appl Microbiol. 2021;15(2):598–603.
O’Brien FJ. Biomaterials & scaffolds for tissue engineering. Mater Today [Internet]. 2011;14(3):88–95. Available from: http://dx.doi.org/10.1016/S1369-7021(11)70058-X
Bose S, Roy M, Bandyopadhyay A. Recent advances in bone tissue engineering scaffolds. Trends Biotechnol [Internet]. 2012;30(10):546–54. Available from: http://dx.doi.org/10.1016/j.tibtech.2012.07.005
Brandys JC, Brandys TM. Wound healing and repair. Surg Attend Rounds. 2015;15–27.
Broad et al. ( 12 ) United States Patent Date of Patent : Syst Method Program a Weigh Scale Usinga Key Signal To Enter a Program Mode. 2009;1(12):14.
Hall Barrientos IJ, Paladino E, Szabó P, Brozio S, Hall PJ, Oseghale CI, et al. Electrospun collagen-based nanofibres: A sustainable material for improved antibiotic utilisation in tissue engineering applications. Int J Pharm [Internet]. 2017;531(1):67–79. Available from: http://dx.doi.org/10.1016/j.ijpharm.2017.08.071
Makrantonaki E, Wlaschek M, Scharffetter-Kochanek K. Pathogenese von Wundheilungsstörungen bei älteren Patienten. JDDG - J Ger Soc Dermatology. 2017;15(3):255–75.
26. Eltom A, Zhong G, Muhammad A. Scaffold Techniques and Designs in Tissue Engineering Functions and Purposes: A Review. Adv Mater Sci Eng. 2019;2019.
Chen H, Truckenmüller R, Van Blitterswijk C, Moroni L. Fabrication of nanofibrous scaffolds for tissue engineering applications. Nanomater Tissue Eng Fabr Appl. 2013;158–83.
Al. R et. United States Patent Date of Patent. Syst methods Robot gutter Clean along an axis Rotat. 2002;1(12):14.
Raeisdasteh Hokmabad V, Davaran S, Ramazani A, Salehi R. Design and fabrication of porous biodegradable scaffolds: a strategy for tissue engineering. J Biomater Sci Polym Ed [Internet]. 2017;28(16):1797–825. Available from: http://doi.org/10.1080/09205063.2017.1354674
Calori IR, Braga G, de Jesus P da CC, Bi H, Tedesco AC. Polymer scaffolds as drug delivery systems. Eur Polym J [Internet]. 2020;129(September 2019):109621. Available from: https://doi.org/10.1016/j.eurpolymj.2020.109621
Reddy MSB, Ponnamma D, Choudhary R, Sadasivuni KK. A comparative review of natural and synthetic biopolymer composite scaffolds. Polymers (Basel). 2021;13(7).
Oktay B, Kayaman-Apohan N, Erdem-Kuruca S, Süleymanoğlu M. Fabrication of collagen immobilized electrospun poly (vinyl alcohol) scaffolds. Polym Adv Technol. 2015;26(8):978–87.
Mehrasa M, Anarkoli AO, Rafienia M, Ghasemi N, Davary N, Bonakdar S, et al. Incorporation of zeolite and silica nanoparticles into electrospun PVA/collagen nanofibrous scaffolds: The influence on the physical, chemical properties and cell behavior. Int J Polym Mater Polym Biomater. 2016;65(9):457–65.
Wu Z, Kong B, Liu R, Sun W, Mi S. Engineering of corneal tissue through an aligned PVA/collagen composite nanofibrous electrospun scaffold. Nanomaterials. 2018;8(2).
Masson-Meyers DS, Andrade TAM, Caetano GF, Guimaraes FR, Leite MN, Leite SN, et al. Experimental models and methods for cutaneous wound healing assessment. Int J Exp Pathol. 2020;101(1–2):21–37.
Kumar P, Honnegowda T. Effect of limited access dressing on surface pH of chronic wounds. Plast Aesthetic Res. 2015;2(5):257.