Main Article Content
Chronic wound is a major challenge worldwide. It imparts burden over Health-Related Quality of Life. Use of Natural Polymers has imparted to body’s native Extracellular Matrix rejuvenating structure and elasto-mechanical characteristics in tissue regeneration and these novel nanofibric composites act far better compared to conventional formulation over loss of medicament (gel, ointment, cream) , adherence to the skin, ease of application and removal if any complications. Recent trends over the use of Electrospinning for the fabrication of fibrous composites ease the preparation with the economic benefits. Comparative market search states the leading gap over the Indian products for wound healing composites and need to be concerned to prioritize research in regenerative tissue scaffolds and its manufacturing techniques. Risk Assessment tool comprehends predictive variability and its impact towards the quality of product. Planning a control strategy for the process with the OFAT approach for the optimization of the process can give a higher quality product. The optimized batch was blended with the Poly (vinyl alcohol) and Collagen for the fabrication of nanofibers. Characterization states the high porous network was formed. This nano fibrous scaffolds were subjected to in-vivo animal model for wound healing. Based on results of requisite findings, it can be concluded that novel composites serves a promising approach over the compromised wound healing.
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