TY - JOUR AU - Girish, Nilkhil AU - Kale, Mohan AU - Bhale, Gauri PY - 2023/01/11 Y2 - 2024/03/29 TI - The Relevance of Acute Phase Reactants in Dermatology JF - Journal of Coastal Life Medicine JA - JCLM VL - 11 IS - 1 SE - Articles DO - UR - https://www.jclmm.com/index.php/journal/article/view/748 SP - 2689 - 2694 AB - <p>Liver proteins called “Acute Phase Reactants (APRs)” respond to inflammation, infection, and tissue injury. APRs are biomarkers for psoriasis, systemic lupus erythematosus, hidradenitis suppurativa, vitiligo, rosacea, and autoimmune bullous disorders like pemphigus vulgaris and bullous pemphigoid.</p><p>CRP is a well-studied APR. Psoriasis and lupus erythematosus have high CRP values. Serum CRP levels correlate with psoriasis severity and may be a treatment target. CRP also indicates disease activity in lupus.</p><p>Hidradenitis suppurativa, a chronic skin condition, causes painful nodules, abscesses, and sinus tracts in the axillary, inguinal, and anogenital areas. Hidradenitis suppurativa patients exhibit high APRs, particularly CRP, which correspond with disease severity.</p><p>Vitiligo, an autoimmune disorder, causes skin regions to lose colour. Vitiligo patients had higher haptoglobin and ceruloplasmin levels.</p><p>Rosacea causes facial flushing, erythema, papules, and pustules. APRs including serum amyloid A, alpha-1-antitrypsin, and haptoglobin may be rosacea biomarkers.</p><p>Autoantibodies targeting skin structure proteins cause blistering and erosion in autoimmune bullous disorders. Pemphigus vulgaris and bullous pemphigoid patients had increased CRP and haptoglobin.</p><p>In conclusion, APRs have emerged as important biomarkers in dermatology, providing valuable information about disease activity, severity, and response to therapy. While more research is needed to fully understand the role of APRs in skin diseases, their potential as diagnostic and therapeutic targets is promising.</p> ER -